Non-Hodgkin's lymphoma treatments
If you have a non-Hodgkin's lymphoma (NHL), your healthcare team will develop a treatment plan just for you. It will be based on your needs and specific information about cancer. When your care team decides what treatments you propose for the NHL, it takes into consideration the following elements:
The NHL typeThe stage of cancer
The grade of cancer – indolent NHL (low grade, or slow evolution) or aggressive (high grade, or rapid evolution)
Your prognostic factors
Your age
Your overall health
Previous administration of a treatment for the NHL
You may be offered an association of the following treatments for the NHL.
ChemotherapyThe chemotherapeutic agents employed depend on the type of NHL and its stage. You can administer a single chemotherapeutic agent or associate some of them. High-dose chemotherapy is used in preparation for a stem cell transplant.
Biological therapyOne can only administer a biological therapy or associate it with chemotherapy to treat certain types of NHL.
Targeted treatmentYou can only administer targeted medications or involve them in chemotherapy to treat certain types of NHL. Some targeted medications allow radiation to be routed directly to lymphoma cells. This treatment is called radioimmunotherapy.
RadiotherapyExternal radiation can only be used as a primary treatment for some early stage NHL types that have not spread to different parts of the body. It can also be associated with chemotherapy to treat an aggressive NHL or more advanced stage.
Sometimes, external radiation therapy is administered to the whole body (total bodily irradiation) in preparation for a stem cell transplant. It can also be administered to the brain (commonly known as brains) to prevent the NHL from propagating to the central nervous system (CNS) or to treat an NHL at the CNS.
It is possible that doctors use radiation therapy to reduce the size of the tumor or larger than normal lymph nodes that exert pressure on nerves, causing pain. Administering radiation therapy in these areas can help reduce the size of large tumors and relieve pain.
Vigilant ObservationVigilant observation is also called active surveillance. It may be an option for some types of indolent NHL that do not yet cause symptoms. The care team is closely monitoring the appearance of signs that indicate that the NHL is progressing. It starts treatment if the disease evolves and causes symptoms.
SurgerySurgery is mainly used to remove a lymph node in part or in full in order to diagnose an NHL. We sometimes do surgery to remove the spleen (splenectomy). In some cases, surgery may be used to remove the entire tumor if it has not invaded the surrounding tissues or organs.
Stem cell transplantStem cell transplants may be used to treat certain individuals whose risk of recurred is high and are in remission. A stem cell transplant can also be done to treat an NHL that reappears (relapse) after being treated or reacting to treatment.
FollowedFollow-up after treatment is an important component of care for people with cancer. You will need to have regular follow-up visits. They are usually planned every two months for the first year or more, then gradually you will meet the doctors less and less often. These visits allow the care team to monitor your progress and find out how you are recovering from treatment.
Clinical trialsSome of the NHL clinical trials are underway in Canada and accept participants. Clinical trials are designed to find new methods of cancer prevention, detection and treatment that are better. Learn more about clinical trials
Questions to ask about treatmentIn order to make the right decisions for you, ask questions about the treatment to your care team.
indolent non-Hodgkin's lymphoma treatments
In the presence of indolent (slow-changing) non-Hodgkin's lymphoma (NHL), the following treatment options may be used. Your healthcare team will offer treatments based on your needs and discuss with you to develop a treatment plan. The treatments proposed depend on the indolent NHL stage, i.e. limited (stage 1 or 2) or advanced (Stage 3 or 4). Doctors also take into consideration the type of NHL, your age and overall health when they plan the treatment.
Some NHL indolent grow slowly and can cause only a few symptoms by developing. They have often already spread to different parts of the body and are at an advanced stage when the initial diagnosis is posed.
The indolent NHL often responds well to treatment and can often be controlled for many years. Some people with an indolent NHL never need to be treated. The indolent NHL has a tendency to reappear (recurrence) after treatment. It can also become resistant to treatment over time. Some indolent NHL can also turn into a more aggressive type of NHL and thus be treated like this type of NHL.
indolent NHL treatments of limited stage
In the presence of a limited-stage (slow-moving) NHL, the following treatment options may be used.
Radiotherapy
The main use of external radiation therapy is when only 1 or few groups of lymph nodes contain lymphoma cells. It is also called radiation therapy of the field reached since it is administered to the affected regions. It is also possible to administer it to the neighbouring lymph nodes.
Vigilant Observation
It is possible that we do not need to treat the NHL indolent immediately as it evolves slowly. There may be no change for long periods of time. Vigilant observation, also known as active surveillance, can be offered to some people who do not have symptoms. Your healthcare team will carefully monitor the NHL and use tests and exams to check whether it is evolving or if your condition is worsening. She starts treatment when the NHL evolves and causes symptoms.
Chemotherapy
Doctors can offer chemotherapy to some people with a limited stadium indolent NHL. It may be a treatment option if a person is not able to receive radiation therapy because it is not possible to include the entire NHL in the field and the NHL causes symptoms. A single chemotherapeutic agent can be administered, but we usually associate some. Sometimes a biological drug is administered with chemotherapeutic agents.
You can use only one of these medications:
Fludarabine (Fludara)
Bendamustine (Treanda)
Chlorambucil (Leukeran)
The associations of chemotherapeutic agents most often administered to treat the indolent NHL at a limited stage are as follows:
CHOP – Cyclophosphamide (Cytoxan, Procytox), doxorubicin (Adriamycin), vincristine (Oncovin), and prednisone
R-Chop – Chop with rituximab (Rituxan)
CVP – cyclophosphamide, vincristine and prednisone
R-CVP – CVP with rituximab
Targeted treatment
Targeted treatment with chemotherapy for some limited-stage NHL indolent can be proposed. Rituximab (Rituxan) is the most commonly used targeted drug, and only for B-lymphocyte lymphomas.
Advanced Stadium indolent NHL treatments
In the presence of an indolent (slow-moving) NHL with advanced stage, the following treatment options may be used.
Vigilant Observation
Vigilant observation can be offered to some people who do not experience symptoms. Just as in the case of the indolent NHL of limited stage, treatment begins when the NHL changes and causes symptoms.
Chemotherapy
Chemotherapy is administered when the late-stage indolent NHL causes symptoms or seems to evolve. Chemotherapeutic agents can be administered alone, but usually some are associated.
Chemotherapy agents that can be administered alone are among other things:
Fludarabine
Bendamustine
Chlorambucil
Cyclophosphamide
The associations of chemotherapeutic agents most often administered to treat the late-stage indolent NHL are as follows:
CHOP – cyclophosphamide, doxorubicin, vincristine and prednisone
R-Chop – Chop with rituximab
CVP – cyclophosphamide, vincristine and prednisone
R-CVP – CVP with rituximab
BR – Bendamustine and rituximab
Radiotherapy
External radiation therapy can also be administered to specific regions in order to control the symptoms of a late-stage indolent NHL.
Targeted treatment
Targeted treatment for certain advanced-stage indolent B-lymphocyte lymphomas may be proposed. Rituximab is the most widely used targeted drug. It can be administered alone, but it is usually associated with chemotherapy.
indolent recurrent or refractory NHL treatments
The indolent NHL (slow Evolution) may reappear (repeat) many times. It can also become refractory over time, which means that treatments have ceased to be effective. Some indolent NHL can transform or re-offend into a more aggressive (fast-paced) NHL type. The disease is treated like an aggressive NHL.
In the presence of an indolent recurrent or refractory NHL, the following treatment options may be used.
Chemotherapy
Doctors may use chemotherapeutic agents they used the first time to treat the NHL if they reacted well. Sometimes the doses administered are different from the first time or stronger.
Physicians may propose to administer only one of these chemotherapeutic agents to treat an indolent recurrent or refractory NHL:
Fludarabine
Bendamustine
Chlorambucil
Cyclophosphamide
The associations of chemotherapeutic agents most often administered are among other things:
Chop
R-CHOP
Cvp
R-CVP
Br
FND – Fludarabine, Mitoxantrone (Novantrone) and dexamethasone (Decadron, Dexasone)
Targeted treatment
Targeted treatment for indolent recurrent or refractory B lymphocyte lymphoma can be proposed. Rituximab is the most widely used targeted drug and can be administered alone or as part of an association chemotherapy. Other medications, such as ibritumomab (Zevalin), can be used if chemotherapy and rituximab do not appear to work.
Stem cell transplant
A stem cell transplant may be proposed to some people with an indolent recurrent or refractory NHL if other treatments are not effective.
Radiotherapy
An external radiation therapy can be administered for a recurrent NHL. Doctors can use it to reduce the size of the tumor or larger than normal lymph nodes that exert pressure on nerves, causing pain. Administering radiation therapy in these areas can help reduce the size of large tumors and relieve pain.
Clinical trials
You may be asked if you want to participate in a clinical trial on the NHL. Learn more about clinical trials
0 komentar:
Posting Komentar